October is designated as National Breast Cancer Awareness Month (NBCAM) a collaboration of national public service organizations, professional medical associations, and government agencies working together to promote breast cancer awareness, share information on the disease, and provide greater access to services.
However, the NBCAM is dedicated to raising awareness and educating individuals about breast cancer throughout the year, encouraging you to regularly visit these sites to learn more about breast cancer, breast health, and the latest research developments.
Studies have discovered the link between estrogen metabolism and breast cancer risk. The DNA polymorphisms related to the production of estrogen play an important role in the development of hormone-sensitive breast and endometrial cancer.
Tom A Malterre, MS, CN, co-author of the Whole Life Nutrition Cookbook gives us an explanation to better understand, and support estrogen metabolism in a patient who doesn’t like vegetables such as broccoli, brussels-sprouts, cauliflower, and cabbage.
“Hormones are tightly regulated in the human body as too high of levels can cause serious problems. As a result, they are put through liver metabolism much like toxicants are, and will go through both Phase 1 and Phase 2. With estrogen the goal is to get the estrogen/estrone to be hydroxylated to form a 2-hydroxyestone. We can do this by encouraging the expression/activity of CYP 1A1/1A2. I-3-C/DIM (Thorne I-3-C) does this quite well. The second step for optimal metabolism of estrogen involves the “Phase 2” enzymes. They will transfer multiple substrates on to the hydroxylated, making them able to be excreted from the body. The best substance to upregulate the expression of the “Phase 2” enzymes is sulforphane (Crucera-SGS). Once the estrogen conjugates are passed into the bile and then the intestines via the gallbladder, they must bind to soluble fiber to assist with excretion. If there is a non-beneficial bacterial overgrowth in the intestines, the bacterium may produce a beta-glucuronidase enzyme that will cleave the estrogen from glucuronate. That allows it to be reabsorbed into the body (not good). There are two ways to decrease this from happening: fix the imbalance in the gut bacterium (FloraMend) 2, or increase the substrate to re-conjugate (Calcium-D-Glucurate).”
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